Team Venture composes the central characters in the show; they live in a fortified compound in or near Colorado Springs, CO United States. Originally a terrorist organization (an homage to G. Joe's Cobra Command) that was the primary adversary of the O.
The Fraternity of Torment is one of a handful of supervillain organizations other than the Guild of Calamitous Intent. As a result of "Love Bheits", Ünderbheit is deposed and Ünderland becomes a democratic society. Ünderland also had no prisons, as all crimes are subject to the death penalty. At the end of season 4 and the beginning of season 5, the members of S. Once led by Baron Werner Ünderbheit in a dictatorship, he ruled the land and had a forced conscription for all men age 18 and a forced euthanasia at 40. mantle, along with their leftover equipment, to create an organization to deal with rogue supervillains (those who do not abide by the rules of organized villainy mandated by institutions like the Guild of Calamitous Intent). (itself a pastiche of Cobra Command) in the Pyramid Wars, during which the original S. Ünderland is a micronation smaller than the state of Delaware and located near Michigan.
After escaping Guild custody later on, Phantom Limb teamed up with Richard Impossible to found the current Revenge Society, which has since had quick success in the field of villainy (though there are only six members) and they fail to kill Dr. The group has effectively been broken up as of "All this and Gargantua-2".
In "All This and Gargantua-2", most of the Council of 13 is killed by the Sovereign as part of a gambit to draw out the Investors. Its founder is Phantom Limb, who initially created the society as his "team" to obtain the ORB for use against the Guild; however, this version of the Revenge Society was merely Phantom Limb himself along with a coffee mug named Wisdom, a toaster named Chuck, and a shoe called Lady Nightshade that he believed (possibly deludedly) were real people.
The current incarnation of the Guild (or at least its leadership) is implied to be a haven for missing and/or presumed deceased rock stars. A new, independent organization of villains set up primarily to oppose the Guild of Calamitous Intent; as such, a number of its members have had unpleasant dealings with the Guild in the past.
It is led by a mysterious figure known only as "The Sovereign" (thought to be David Bowie, but later revealed to be a nameless shapeshifter), and a group of villains called the Council of Thirteen. The Guild then split over how to use the ORB, with Fantomas founding the Guild of Calamitous Intent (who wanted to use the ORB to control mankind) while Lloyd founded the modern version of the OSI (who wanted to use the ORB to help mankind).
As Brock Samson put it: "These guys like their system, it's what they do; you take that away, and you're looking at a bunch of pissed off nut-bags with ray guns." The Guild not only serves to organize those mentally unstable individuals prone to acts of villainy into an efficient force, but at the same time it also acts as a brake on their more murderous impulses, as well as restricting attacks to Guild-approved targets. The current incarnation of the Guild was apparently founded around 1959 by Phantom Limb's grandfather, but its history can be traced back to the late Victorian era, where it was a heroic organization led by Colonel Lloyd Venture, Rusty Venture's grandfather, dedicated to the protection of an item known as the "ORB", an enigmatic sphere that had been built over the centuries by humanity's greatest individuals.
It acts as a sort of supervillain trade union, providing benefits such as health insurance and setting the rules of conduct between its members and their enemies; the Guild acts as a stabilizing influence on the world of super-villainy, as without it they would be unchecked free agents with no rules restricting their behavior. Season six introduces the New York branch of the Guild, which is made up of the most dangerous supervillains the organization has to offer.